Adverse Reactions

Hepatic:

Hepatocellular neoplasms and peliosis hepatis have been reported in association with long-term androgenic anabolic steroid therapy
Genitourinary System:

In men. a. Prepubertal: Phallic enlargement and increased frequency of erections. b. Postpubertal: Inhibition of testicular function, testicular atrophy and oligospermia, impotence, chronic priapism, epididymitis and bladder irritability.

In women: Clitoral enlargement, menstrual irregularities.

In both sexes: Bncreased or decreased libido.

CNS:

Habituation, excitation, insomnia, depression.

Gastrointestinal:

Nausea, vomiting, diarrhea.

Hematologic:

Bleeding in patients on concomitant anticoagulant therapy.
Breast:

Gynecomastia.

Larynx:

Deepening of the voice in women.

Hair:

Hirsutism and male pattern of baldness in women.

Skin:

Acne (especially in women and prepubertal boys.)

Skeletal:

Premature closure of epiphyses in children.

Fluid and Electrolytes:

Edema, retention of serum electrolytes (sodium, chloride, potassium, phosphate, calcium).

Metabolic/Endocrine:

Decreased glucose tolerance, increased serum levels of low-density lipoprotein and decreased levels of high-density lipoprotein  increased creatine and creatinine excretion, increased serum levels of creatinine phosphokinase (CPK). Some virilizing changes in women are irreversible even after prompt discontinuance of therapy and are not prevented by concomitant use of estrogens.


                       
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